Postmenopausal Osteoporosis Is Associated with Serum Chemerin and Irisin but Not with Apolipoprotein M Levels
Journal of Menopausal Medicine
;
: 76-79, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-65939
ABSTRACT
OBJECTIVES:
The objective of this study was to describe the levels of chemerin, irisin and apolipoprotein M (apoM) in women with postmenopausal osteoporosis.METHODS:
The study included 88 women with postmenopausal osteoporosis. Based on World Health Organization criteria, women with a T-score of ≤–2.5 were defined as osteoporotic. In this case-control study, postmenopausal women with T-score >–1 were selected as controls (n = 88) and case-matched in a 11 ratio based on age (within 2 years) and body mass index (BMI) (within 1.0 kg/m2). ApoM, irisin and chemerin levels were determined by a commercially available enzyme-linked immunosorbent assay (ELISA) kit.RESULTS:
There were no significant differences in age, BMI, parity, cholesterol and apoM levels between the two groups. C-reactive protein levels were significantly increased in women with osteoporosis. Serum chemerin levels (240.1 ± 46.1 vs. 261.5 ± 50.8 ng/mL) were significantly lower in the women with osteoporosis, as compared to the controls (P = 0.004). Serum irisin levels were also decreased in women with osteoporosis (0.7 ± 0.2 vs. 0.8 ± 0.2 ng/mL; P = 0.007).CONCLUSION:
In the present study, osteoporosis was associated with decreased levels of circulating chemerin and irisin. These findings suggested that adipokines might play a role in the pathogenesis of osteoporosis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteoporosis
/
Paridad
/
Apolipoproteínas
/
Organización Mundial de la Salud
/
Proteína C-Reactiva
/
Ensayo de Inmunoadsorción Enzimática
/
Índice de Masa Corporal
/
Estudios de Casos y Controles
/
Osteoporosis Posmenopáusica
/
Colesterol
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Journal of Menopausal Medicine
Año:
2016
Tipo del documento:
Artículo
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