IL-6/JAK/STAT3/SOCS3 signaling pathway:potential therapeutic effect on inflammatory bowel disease / 国际儿科学杂志

ABSTRACT

Interleukin-6(IL-6)is a pleiotropic cytokine with central roles in immune and inflammatory reactions through downstream activation of the Janus kinase 2/signal transducer and activator of transcription 3 /Suppressor of cytokine signaling3 ( JAK/STAT3/SOCS3 ) signaling pathway. Additionally, dysregulation of the interleukin( IL)-6-mediated JAK/STAT3/SOCS3 signaling pathway is closely related to the development of in-flammatory bowel disease( IBD) . On this basis,modulation of the IL-6/JAK/STAT3/SOCS3 signaling pathway is currently being widely explored to develop novel therapies for IBD. The present review details the mechanisms and roles of the IL-6/JAK/STAT3/SOCS3 pathway in IBD, describes current therapeutic strategies, and the search for potential therapeutic approaches to treat IBD.