The peritoneal dialysis efficacy of icodextrin-based solution:a Meta-analysis / 天津医药

ABSTRACT

Objective To compare the efficacy of icodextrin-based solution (ico) and glucose-based solution (GLU) in peritoneal dialysis patients. Methods Pubmed (1996-2016.12), MEDLINE (1996-2016.12), Embase (1974-2016.12) and Cochrane library were searched by two independent investigators who conducted quality assessment and data mining and performed Meta-analysis using RevMan 5.2. Results Ten randomized controlled trials with 825 participants were included in this study, and 661 patients completed the trials at last. The Meta-analysis showed that there were no significant differences in body weight (WMD=-1.88, 95%CI-4.68-0.93, P=0.19), fasting plasma glucose (WMD=-0.76, 95%CI-1.79-0.28, P=0.15), plasma triglycerides (WMD=-0.56, 95%CI-1.18-0.06, P=0.08), plasma total cholesterol (WMD=-0.17, 95%CI-0.63-0.29, P=0.47) and adverse events (RR=1.06, 95%CI0.86-1.29, P=0.59) between ICO group and GLU group. The peritoneal creatinine clearance (WMD=0.48, 95%CI0.27-0.68,P<0.001) and peritoneal urea clearance (WMD=0.44, 95%CI0.23-0.66, P<0.001) were better in ICO group than those of GLU group. Conclusion ICO can provide a better peritoneal creatinine clearance and peritoneal urea clearance, and which has the same safety compared with GLU.