Efficacy and safety of long-term use of low dose glucocorticoids in acute respiratory distress syndrome / 实用医学杂志
The Journal of Practical Medicine
; (24): 3092-3095, 2017.
Article
en Zh
| WPRIM
| ID: wpr-661359
Biblioteca responsable:
WPRO
ABSTRACT
Objective To explore the ef fi cacy and safety of long-term use of low dose glucocorticoids in acute respiratory distress syndrome (ARDS). Methods Fifty ARDS patients were randomly divided into two groups. The control group(25 patients)received non-invasive or invasive mechanical ventilation,antibiotics and support treatments. The glucocorticoids group(25 patients)received the same treatments plus long-term use of low dose glucocorticoids. Results The mortality in glucocorticoids group(32%(8/25))was much lower than that in the control group(60%(15/25))(P < 0.05). The ventilator-free days and organ failure-free days within 28d in glucocorticoids group were significantly higher than those in the control group (P < 0.05). The oxygenation index and the serum IL-8 levels in glucocorticoids group at 14d and 28d were higher than those in the control group(P<0.05). Compared to the control group ,long-term use of low dose glucocorticoids in ARDS did not increase fasting blood-glucose at 7d,gastrointestinal bleeding and hospital infections within 28d. Conclusions Long-term use of low dose glucocorticoids in ARDS could reduce the serum IL-8 levels and improve the prognosis.
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WPRIM
Idioma:
Zh
Revista:
The Journal of Practical Medicine
Año:
2017
Tipo del documento:
Article