Lung stem cell-based therapy:a possible way to repair the injuried lung / 国际儿科学杂志

ABSTRACT

Recently,the promising features of lung stem cells,including ability to differentiate into di-verse cell lineages and their regenerative properties,have aroused researchers′ attention,which offers intriguing perspectives on cell-based therapies for end stage lung disease. Associated with various stem cell phenotypes, lung stem cell has been proved to differentiate into cell lineages, such as endothelial, epithelial cell and secret cells,which reconstitute the injured lung then lead to lung regeneration. In the present paper,a comprehensive re-view of stem cell-based clinical trials conducted worldwide that scrutinizes biological properties of lung stem cells and highlights lung stem cell therapeutic effects is elaborated. To date,there is no regulatory approved cell treatment for end stage lung disease,but research and clinical studies offer the hope for successful cell therapy in the next decades.