Long-Term Outcomes of Chemoradiation for Anal Cancer Patients
Yonsei Medical Journal
;
: 108-115, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-66234
ABSTRACT
PURPOSE:
The aim of this study was to evaluate long-term oncologic outcomes after concurrent chemoradiation treatment for anal cancer. MATERIALS ANDMETHODS:
Between January 1979 and December 2008, the records of 50 consecutive patients with anal cancer and who were treated by chemoradiation or radiation only with a curative intent were retrospectively reviewed. The oncologic outcomes and the risk factors for recurrence were analyzed.RESULTS:
Of the 50 patients, 49 underwent concurrent chemoradiation and one underwent radiation only. After these definitive treatments, 43 (86.0%) achieved a clinical complete response. During the median follow-up of 60 months (range 2-202 months), the 5-year overall survival, disease-free survival, and locoregional recurrence-free survival were 84.2%, 72.7%, and 69.9%, respectively. Multivariate analysis revealed that the performance status (p=0.031) and a clinical complete response (p=0.039) were the independent predictors for overall survival; lymph node involvement (p=0.031) was the only independent predictor for disease-free survival.CONCLUSION:
The performance status and a clinical complete response may be reliable predictors of survival after chemoradiation for anal cancer. The addition of irradiation to the inguinal area may not be significantly associated with the outcomes.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias del Ano
/
Pronóstico
/
Recurrencia
/
Factores de Tiempo
/
Modelos de Riesgos Proporcionales
/
Estudios de Seguimiento
/
Resultado del Tratamiento
/
Supervivencia sin Enfermedad
/
Quimioradioterapia
/
Metástasis Linfática
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adulto
/
Anciano
/
Aged80
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Yonsei Medical Journal
Año:
2013
Tipo del documento:
Artículo
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