Differential expression and clinical significance of microRNA in early esophageal squamous cell carcinoma / 国际检验医学杂志

ABSTRACT

Objective To explore the differential expression and clinical significance of microRNA in early esophageal squamous cell carcinoma .Methods From April 2013 to April 2016 ,65 cases of early esophageal squamous cell carcinoma patients were recrui-ted into esophageal squamous cell carcinoma group ,meanwhile 65 healthy person were recruited into control group ,then analyze the significance of microRNA in the diagnosis of early esophageal squamous cell carcinoma and the relationship between the expression of microRNA and radiotherapy .Results The levels of microRNA-21 and microRNA-205 in esophageal squamous cell carcinoma group were significantly higher than those in healthy group(P<0 .05) .The sensitivities of microRNA-21 and microRNA-205 in the diagnosis of esophageal squamous cell carcinoma were 89 .23% ,84 .62% ,the specificity were 96 .92% ,95 .38% respectively .The sensitivity of radiotherapy in cancer tissues with high expression of microRNA-21 and microRNA-205 was significantly higher than that in cancer tissues with low expression (P< 0 .05) .Conclusion MicroRNA is important to assist the diagnosis of esophageal squamous cell carcinoma ,and according to the expression of microRNA ,the sensitivity to radiotherapy could be evaluated ,which could guide clinicians to select proper treatment strategies to improve therapeutic effect .