Clinicopathologic analysis of ten patients with gonadal diffuse large B-cell lymphoma / 白血病·淋巴瘤

ABSTRACT

Objective To investigate the clinicopathologic characteristics,immunophenotype,differential diagnosis,and prognostic factors of gonadal diffuse large B-cell lymphoma(DLBCL).Methods The clinicopathologic data of 10 patients with gonadal DLBCL including morphology and immunohistochemistry were analyzed retrospectively,then the literature was reviewed.Results Among 10 patients,9 cases were testicular DLBCL,and the median age was 67 years old(40-85 years old); 1 case was ovary DLBCL,and the age was 46 years old.Tumor cells were large to medium-sized under the optical microscope,which were characterized as diffuse infiltration around the duct and the remaining convoluted tubule of testis neoplasms.Most DLBCL(70%,7/10)immunophenotype analysis showed non-germinal center B-cell(non-GCB)type.Patients were followed up from 6 to 103 months,and 2 patients lost follow-up.The survival number of patients in 1-year,3-year,and 5-year was 4,2,2 respectively.Conclusions Primary gonadal DLBCL is an uncommon extranodal lymphoma,which mainly belongs to non-GCB type with poor prognosis.Comprehensive treatments usually take operation and chemotherapy,and the prognosis should be evaluated by multiple factors.