Application of ritodrine hydrochloride combined with magnesium sulfate in gestational diabetes mellitus pregnant women with threatened premature labor / 中国基层医药

ABSTRACT

Objective To explore the effect of ritodrine hydrochloride combined with magnesium sulfate in gestational diabetes mellitus pregnant women with threatened premature labor.Methods 74 gestational diabetes mellitus pregnant women with threatened premature labor were selected as the research subjects.According to the digital table,they were randomly divided into observation group and control group,37 cases in each group.The control group was treated with magnesium sulfate,the observation group was treated with ritodrine hydrochloride combined with magnesium sulfate.During treatment and after drug withdrawal 3 days,the fasting blood glucose levels and postprandial 2h blood glucose levels during pregnancy,prolonged time,complications and neonatal conditions in the two groups were recorded.Results The total effective rate of the observation group was 97.30％,which was significantly higher than 83.78％ of the control group,the difference was statistically significant between the two groups(u =2.336,P =0.019).The fasting blood glucose and 2h postprandial blood glucose levels were higher than before treatment in the two groups,but there were no statistically significant differences between the two groups (t =1.904,P =0.060;t =1.698,P =0.093).After stopping the drug,the fasting blood glucose and 2h postprandial blood glucose of the two groups were reduced to the pre-treatment levels,but there were no statistically significant differences between the two groups (t =0.953,P =0.343;t =0.749,P =0.456).The average gestation duration prolonged time of the observation group was (22.59 ± 2.84)d,which was significantly longer than that of the control group(t =11.737,P =0.000).The neonatal birth weight and Apgar score of the observation group were significantly higher than those of the control group (t =12.746,P =0.000;t =10.159,P =0.000).The neonatal survival rate of the observation group was 97.30％,which of the control group was 93.78％,the difference was statistically significant between the two groups (x2 =3.944,P =0.047).Conclusion Ritodrine hydrochloride combined with magnesium sulfate in the treatment of gestational diabetes mellitus pregnant women with threatened premature labor has good results,and can prolong pregnancy,and has less complications.