Relationship Between Peripheral Blood Eosinophil Level and Acute Myocardial Infarction Combining Helicobacter Pylori Infection / 中国循环杂志

ABSTRACT

Objective: To study the relationship betweenperipheral blood eosinophil(EOS) level and acute myocardial infarction(AMI) combining helicobacter pylori (Hp) infection, to compare EOS level in Hp(+) and Hp(-) AMI patients with the possible mechanism. Methods: A total of 662 patients with coronary heart disease(CHD) admitted in our hospital from 2015-09 to 2016-05 were retrospectively studied. The patients were divided into 2 groups: AMI group, n=269 and Stable angina pectoris(SAP) group, n=393; according to 13C breath test, the patients were divided into another set of 2 groups: Hp(+) group, Hp infection value≥4.0, n=276 and Hp(-) group, Hp infection value<4.0, n=386. Clinical data was collected, EOS levels were compared between Hp(+) and Hp(-) AMI patients; relationship between EOS level and high sensitivity C-reactive protein(hs-CRP) level was analyzed in Hp(+) AMI patients. Results: Compared with SAP group, AMI group had the higher rate of Hp(+) as 46.5%vs38.4%, P=0.024. In Hp(+) group, compared with SAP patients, AMI patients had the lower EOS level and higher hs-CRP level, all P<0.000. In Hp(+) AMI patients, EOS level was negatively related to hs-CRP(r=-0.202, P<0.05). Conclusion:Hp(+) AMI patients had decreased peripheral blood EOS and increased hs-CRP, it implied that Hp(+) may aggravate the inflammatory response in AMI patients and therefore, affect EOS which could play an important role in thrombus formation.