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Effects of miR-143 on invasion and migration of B cell lymphoma cells through regulating expression of PAN3 protein / 中国免疫学杂志
Chinese Journal of Immunology ; (12): 1774-1778, 2017.
Artículo en Chino | WPRIM | ID: wpr-663701
ABSTRACT

Objective:

To investigate the effect of miR-143 on the invasion and migration of B cell lymphoma cells .

Methods:

The expression of miR-143 in normal bone marrow and lymphoma was detected by qPCR .The expression levels of miR-143 in different cell lines were examined by qPCR .qPCR was used to detect the ability of miR-143 on PAN3.The relationship between miR-143 and PAN3 was detected by double luciferase assay .The effect of miR-143 expression on the migration ability of B cell lymphoma E 6-1 cells was examined by scratch test .The effect of miR-143 expression on the invasion ability of B cell lymphoma E 6-1 cells was exa mined by transwell test.

Results:

Compared with normal bone marrow ,miR-143 was down-regulated in B-cell lymphoma.Double luciferase assay showed that miR-143 could regulate the expression of PAN 3.Overexpression of miR-143 ,E6-1 cells significantly reduced the ability to attack and migrate.

Conclusion:

miR-143 can regulate the migration and invasion of B cell lymphoma cells by regulating the expression of PAN3.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Journal of Immunology Año: 2017 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Journal of Immunology Año: 2017 Tipo del documento: Artículo