Analysis on the prevalence and risk factors of fatty liver in male patients / 中国综合临床

ABSTRACT

Objective To analyze the prevalence of fatty liver in male patients and to explore the risk factors of the disease,so as to provide theoretical basis for the prevention and treatment of fatty liver in male patients.Methods A total of one thousand seven hundred and eight male patients with physical examination in 2016 in Tangshan Third Hospital were selected, and 488 cases of fatty liver were diagnosed by ultrasonography.The prevalence of fatty liver in male patients with different characteristics was analyzed,the difference of blood biochemical indexes between fatty liver and non fatty liver groups was compared,and the non-conditional logistic regression model was used to explore the risk factors affecting the prevalence of fatty liver in males.Results The prevalence rate of fatty liver in males was 28.6%(488/1708).The results of multivariate logistic regression analysis showed that the individual characteristics(age,BMI,smoking,drinking)and biochemical indexes(FPG,TC,TG,HDL-C,LDL-C)had significant effects on the prevalence of fatty liver in male patients(P<0.05).The prevalence rate of fatty liver increased with age(χ2=77.321,P<0.05),the prevalence rates of<40 years old,≥40 years-<50 years,≥50 years-<60 years,above 60 years were 14.9%(68/488),25.0%(80/488),32.7%(132/488),39.4%(208/488)respectively.Overweight,obesity,smoking and drinking increased the risk of fatty liver disease,and the OR values were 3.173,4.175,2.401 and 3.249 respectively.The biochemical indexes FPG,TC,TG,LDL-C in the fatty liver group((7.61 ± 2.85)mmol/L, (6.55±1.52)mmol/L,(1.97±0.68)mmol/L,(3.18±0.93)mmol/L)were higher than those in the non fatty liver group((5.17 ±1.37)mmol/L,(5.49 ± 1.46)mmol/L,(1.47 ± 0.71)mmol/L,(2.86 ± 0.81)mmol/L),the differences were statistically significant(t=580.648,220.727,176.356,33.596,P<0.05),HDL-C was lower than that in non fatty liver group((1.18 ± 0.38)mmol/L vs.(1.29 ± 0.41)mmol/L,t =42.261,P<0.05).Conclusion The prevalence of male fatty liver was higher.Age,obesity,smoking,alcohol consumption, glucose metabolism and lipid metabolism disorder were closely related to the occurrence of fatty liver in male.