The relationship between serum Dickkopf-1 ,HE4 and PARP-1 levels and clinical staging of gastric cancer and lymph node metastasis and its clinical prognosis / 国际检验医学杂志

ABSTRACT

Objective To investigate the relationship between serum Dickkopf-1 ,HE4 and PARP-1 levels and clinical staging of gastric cancer and lymph node metastasis and its clinical prognosis .Methods The serum levels of DKK-1 ,HE4 and PARP-1 in 50 patients with gastric cancer (gastric cancer group) and 50 healthy volunteers (control group) were measured by enzyme-linked im-munosorbent assay (ELISA) ,the relationship between serum Dickkopf-1 ,HE4 and PARP-1 levels and clinical staging of gastric cancer ,lymph node metastasis was analyzed .and the clinical prognosis was explored .Results Serum DKK-1 ,HE4 ,PARP-1 levels of gastric cancer group were (29 .6 ± 9 .6) ,(52 .6 ± 18 .6) ,(6 .1 ± 1 .8)μg/L respectively ,and the levels of control group were (5 .8 ± 1 .5) ,(17 .5 ± 2 .6) ,(3 .6 ± 1 .8)μg/L respectively .Serum DKK-1 ,HE4 and PARP-1 levels of gastric cancer group were signifi-cantly higher than those of control group ,DKK-1 ,HE4 ,PARP-1 levels were higher in gastric cancer patients with older age ,lower degree of differentiation ,in late clinical stage ,and with lymph node metastasis ;serum DKK-1 ,HE4 ,PARP-1 levels had no obvious relationship with gender and age but were positively related to TNM stage ,and lymph node metastasis ;DKK-1 (P=0 .04) ,HE4 (P=0 .03) and PARP-1 (P=0 .04) are independent risk factors of poor prognosis of patients with gastric cancer .Conclusion The levels of serum Dickkopf-1 ,HE and PARP-1 in patients with gastric cancer are closely related to the clinical prognosis of the pa-tients and are independent risk factors of poor prognosis .