Progress of transcription factor E3 fusion genes related tumors / 肿瘤研究与临床

ABSTRACT

Transcription factor E3 (TFE3) located in the X chromosome 11.2 plays an important role in cell growth, differentiation and transcription regulation. In the condition of pathology, the TFE3 gene translocates to form fusion genes, which makes the expression of TFE3 protein abnormally high, and affects the transcriptional regulation of cells and promotes the tumor formation. This article reviews the clinicopathological features of several TFE3 fusion genes related tumors,in order to improve the recognition of this disease.