Incidence Trend and Clinical Characteristic Changes of Inpatients with Cervical Adenocarcinoma in the Last Decade / 实用妇产科杂志

ABSTRACT

Objective:To evaluate the incidence trend and clinical characteristic changes of inpatients with cervical adenocarcinoma in the last decade.Methods:A retrospective analysis was performed.99 patients diagnosed with adenocarcinoma of cervix and hospitalized at Peking University First Hospital(PUFH) from January 2006 to May 2016 were included.Patients were divided into two groups according to the year and the results of screening.The clinical characteristics including basic information,diagnostic way and cancer stage were recorded and analysed.Results:①The incidence ratio of cervical adenocarcinoma had been significantly increased in the last decade,while clinical stage was statistically different.②The top three symptoms of cervical adenocarcinoma were irregular vaginal bleeding,bleeding after intercourse,abnormal vaginal discharge,accounting for 37.37％,34.34％ and 8.08％,respectively.There were significant differences in the stage of cervical cancer and the diameter of the lesion(P ＜0.05) after the comparison between the symptomatic group and the asymptomatic group,but there were no differences in differentiation degree,pathological type,lymph node metastasis and resection margin.③ Cytological screening of cervical adenocarcinoma was still dominated by squamous cell changes (42.19％).HPV18 ranked first in HPV detection,accounting for 36.21％ (21/58),however,29.31％ cases were negative in HPV test.There was no significant difference in the age,pathological type,differentiation degree,resection margin and lymph node metastasis between HPV negative and positive patients with cervical adenocarcinoma (P ＞ 0.05).Conclusions:The incidence of cervical adenocarcinoma is increasing year by year.Some patients with cervical adenocarcinoma have negative screening results for cytology and HPV,easy to be missed diagnosis,therefore,more attention should be put into the screening for cervical adenocarcinoma in order to find the cancer earlier.