Regulation system for generation and maintenance of circadian rhythms / 军事医学

ABSTRACT

Circadian rhythms are driven by the transcriptional and translational oscillator and post-transcriptional modification on clock genes (bmall,clock,cry and per) and clock control genes (rev-erbα,rorα,dbp,tefand hlf),which keeps the body's physiologies,behavior,and other life activities and shows roughly 24-hour oscillation.The circadian clock system consists of the central and peripheral clock system,rhythm input and output system.The input system receives and transfers the light signals to the central clock system that functions as the main pacemaker to generate and output the circadian signals to the peripheral organ,which works together with the local endogenous circadian system to maintain the body's physiological activities.A variety of endogenous and exogenous factors,such as light,temperature,time of food intake,nutrients and metabolic related factors,play important roles in regulating the circadian clock system and maintaining homeostasis of circadian rhythms.Here,we focuses on the regulating system and related regulating factors for the generation and maintenance of circadian rhythms.