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Role of acid-sensing ion channel 1a in pathogenesis of autoimmune diseases / 中国药理学通报
Chinese Pharmacological Bulletin ; (12): 12-15, 2018.
Artículo en Chino | WPRIM | ID: wpr-664489
ABSTRACT
Acid-sensing ion channels ( ASICs) are proton-gated channels expressed widely in the central nervous systems and pe-ripheral tissues, among which ASIC1a is a core part and plays an important role in many physiological and pathological proces-ses.As a key receptor for extracellular protons , ASIC1a is in-volved in a variety of pathophysiological processes involving tis-sue acidosis, such as pain, inflammation, seizures and multiple sclerosis.Autoimmune disease is a chronic inflammatory dis-ease , and the excessive activation of T , B cells leads to multiple tissue and organ damage when the body responds to autoantigen immune response . In recent years , studies have found that ASIC1a plays an important role in the development of various au-toimmune diseases.In this paper, the biological characteristics of ASIC1a are briefly reviewed , and the research progress of ASIC1a in the development and progression of autoimmune dis-eases is discussed .

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio de etiología Idioma: Chino Revista: Chinese Pharmacological Bulletin Año: 2018 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio de etiología Idioma: Chino Revista: Chinese Pharmacological Bulletin Año: 2018 Tipo del documento: Artículo