Effect of betaloc combined with lotensin on cardiac function and NT-proBNP level in patients with chronic congestive heart failure / 药物评价研究

ABSTRACT

Objective To analyze the effect ofbetaloc combined with lotensin on cardiac function and N-terminal B type natriuretic peptide (NT-proBNP) level in patients with chronic congestive heart failure (CHF).Methods 210 CHF patients in People's Hospital in Qinghai Province from December 2015 to December 2016 were divided into three groups by random number table,70 cases in each.Three group were given routine examination,cardiotonic and diuretic treatment,and on this basis,control A group purely added lotensin,control B group purely added betaloc,observation goup took betaloc combined with lotensin.The cardiac function,exercise tolerance,NT-proBNP level,concentration of hemoglobin (Hb),heart rate,blood pressure,clinical efficacy and safety before and after treatment were compared among the three groups.Results Before treatment,there was no statistical difference in the cardiac function,NT-pro BNP level and Hb content among three groups;After treatment,the cardiac function and exercise tolerance of observation group were significantly better than those of control A and B group (P ＜ 0.05) The NT-pro BNP level,heart rate and blood pressure of observation group were significantly lower than those of control A and B group (P ＜ 0.05) The Hb content of observation group was higher than that of control A and B group (P ＜ 0.05).The total effective rate of observation group was significantly higher than that of control A and B group (P ＜ 0.05).There was no statistical difference in the incidence of adverse reactions among three groups.Conclusion Betaloc combined with lotensin in treatment of CHF can effectively improve cardiac function,relieve heart failure and increase exercise tolerance of patients,which has clinical application value.