Influence of vancomycin on inflammatory factor and PCT in elderly patients with heart failure combined with pulmonary infection / 药物评价研究

ABSTRACT

Objective To investigate the influence of vancomycin on inflammatory factor and PCT in elderly patients with heart failure combined with pulmonary infection.Methods 64 cases with heart failure combined with pulmonary infection from Jan.2015 to Dec.2016 in our hospital were chosen,who were randomly divided into two groups,who were taken with cephalosporin and vancomycin,the clinical efficacy of two groups after treatment were compared,the BNP,inflammatory factor and PCT level before and after treatment of two groups were compared.Results The total effective rate of vancomycin group was 84.37％,which was significantly higher than that of ceftazidime group,and the difference was statistically significant (P ＜ 0.05).After treatment,the BNP,TNF-a,IL-6,PCT were significantly reduced in the two groups,and the difference was statistically significant (P ＜ 0.05).And the BNP,TNF-a,IL-6,PCT of vancomycin group was decreased more significantly,the difference between the two groups was statistically significant (P ＜ 0.05).Conclusion Vancomycin had great antibacterial action,which had great efficacy in treatment of heart failure combined with pulmonary infection patients.