Research progress on regulation mechanism of epigenetic modifications for drug transporters / 药物评价研究

ABSTRACT

Drug transporters play a key role in drug absorption,distribution and excretion.The distribution and expression of transporters in tissues and organs are regulated by epigenetic modifications,resulting in individual differences of drugs disposition significantly.With the development of epigenetics,researches on the regulation of drug transporters expression based on epigenetic modifications (DNA methylation,histone modification,microRNA interference,etc.) have been more and more reported.In this paper,we will summarize the epigenetic modifications regulating drug transporters.