Role of drug transporters and metabolizing enzymes in pharmacokinetics of antibiotics / 药物评价研究
Drug Evaluation Research
;
(6): 1197-1202, 2017.
Artículo
en Chino
| WPRIM
| ID: wpr-664705
ABSTRACT
In recent years,the research on drag transporters has made great progress,more and more transporters have been found and studied,and they have shown important roles in the transport of drug across the cellular membrane.Various transporters,including uptake transporters and effiux transporters,have important effects on the pharmacokinetics and drug-drug interactions.Studies have shown that the process in vivo of most of the antibiotics was related to transporters and metabolizing enzymes (cytochrome P450 and CYP450).Therefore,this article summarized the latest research progress in pharmacokinetics and drug-drug interactions of transporters and CYP450,so that provides evidence for clinical rational use of antibiotics.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Drug Evaluation Research
Año:
2017
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS