The investigation on the detection value of thyrotropin receptor antibody in children with autoimmune thyroid disease / 国际检验医学杂志

ABSTRACT

Objective To investigate the detection value of thyrotropin receptor antibody(TRAb)in children with autoimmune thyroid disease.Methods During the January 2015 and October 2016,a total of 72 cases of children with autoimmune thyroid dis-ease admitted to our hospital were selected,including 36 cases of Graves disease as the Graves disease group,and 36 cases of Hashi-moto's thyroiditis as Hashimoto's thyroiditis group;36 cases of healthy children in this hospital at the same period were selected as the control group.Children in the Graves disease group and Hashimoto's thyroiditis group were taken routine treament,ane the changes of the serum TRAb level before the treatment and one year after the treatment between the two groups.The positive value range of TRAb level is more than 1.75 U/L,and the positive rate of serum TRAb level before the treatment and one year after the treatment was recorded in the two groups.Results Before treatment,TRAb level of the Graves disease group[(12.79 ± 6.38)U/L]was higher than those in Hashimoto's thyroiditis group[(2.03 ± 0.29)U/L]and the control group[(0.85 ± 0.23)U/L],and the difference was statistically significant(P<0.05);TRAb level of the Hashimoto's thyroiditis group[(2.03 ± 0.29)U/L]was significantly higher than that of the control group[(0.85 ± 0.23)U/L],(P<0.05).After treatment:TRAb level of the Graves disease group[(9.36 ± 12.14)U/L]was significantly higher than those in Hashimoto's thyroiditis group[(1.78 ± 0.38)U/L]and the control group[(0.84 ± 0.29)IU/L],and the difference was statistically significant(P<0.05);TRAb level of the Hashimoto's thyroiditis group was significantly higher than the control group,and the difference was statistically significant(P<0.05).TRAb levels in patients with graves'disease and Hashimoto thyroiditis after treatment were significantly lower than those before treat-ment,and the difference was statistically significant(P<0.05).The positive rates of TRAb level in the Graves disease group before and after treatment were 100%,and the positive rate of TRAb level in Hashimoto's thyroiditis group after treatment(11.11%)de-creased in comparison with the one before treatment(22.22%),and the difference was statistically significant(P<0.05).Conclusion There is a significant change of TRAb level in children with autoimmune thyroid disease.Especially,the change of TRAb level in Graves disease before and after treatment may provide a reference for clinical diagnosis and prognosis evaluation of Graves disease.