Efficacy of midazolam on the persistence of pediatric seizures in patients with diazepam / 药物评价研究

ABSTRACT

Objective To investigate the therapeutic effect and safety of midazolam on the persistence of pediatric patients.Methods 66 cases of pediatric convulsions from January 2014 to December 2016 were enrolled in this study.According into the admission time,34 cases children in the study group were treated with midazepam on the base of control group,the control group of 32 children with diazepam,two groups of children with therapeutic effect and safety were observed.Results The clinical effective rate was 94.12％ in the study group and 75.00％ in the control group.The difference between two groups was statistically significant (P ＜ 0.05).The time of onset and the time of convulsion were lower than those of the control group,the difference was statistically significant (P ＜ 0.05);the respiratory secretions increase of the study group was more than the control group,while who were tolerated.Conclusion Midazolam continuous intravenous infusion treatment of convulsion status,rapid onset,safe and effective,which can be used in the clinical scope.