Comparison of Effects of Dezocine and Dexmedetomidine Hydrochloride on Prevention Pediatric Postoperative Agitation / 医药导报

ABSTRACT

Objective To evaluate the effects and safety of dezocine and dexmedetomidine hydrochloride on the prevention of the pediatric postoperative agitation. Methods A total of 90 pediatric patients undergoing prepuce cerclage were randomly divided into 3 groups(n=30)dezocine group( Group Dez),dexmedetomidine group( Group Dex) and control group ( Group C),all groups were implemented general anesthesia combining with penile dorsal nerve block anesthesia.After induction of anesthesia,Group Dez and Group Dex were given 0.1 mg·kg-1of dezocine and 0.5 μg·kg-1of dexmedetomidine hydrochloride,respectively,Group C was given 0.9% sodium chloride solution.The rate of pediatric agitation,the operating room, the recovery time,the amount of additional propofol during the operation and the adverse reaction incidence within 6 hours after the surgery(circulation and respiratory depression,drowsiness,headache,nausea and vomiting) were observed and recorded. Results All groups have the surgery successfully done.There were no significantly difference among the three groups on the recovery time( P>0.05).The incidence of postoperative agitation was 3.33% in Group Dez,0.00% in Group Dex,46.67% in Group C,respectively( P<0.05 ).All of the pediatrics in three groups were not given additional propofol.There was no obvious adverse reaction at the time of 6 hours after surgery. Conclusion Dezocine and dexmedetomidine hydrochloride both can reduce the rate of postoperative agitation in pediatric patients and have no obvious side effects.Therefore,the clinical use of dezocine and dexmedetomidine hydrochloride are safe and effective.