The differences between miR-27a and miR-23a in patients with premature ovarian failure before and after treatmentand the feasibility of miR for assessing efficacy / 实用医学杂志

ABSTRACT

Objective To investigate the changes of microRNA(miR)-27a and miR-23a in patients with premature ovarian failure(POF)after treatment,and to analyze the feasibility of these miRsfor assessing the efficacy.Methods 77 women with POF and 50 healthy women were assigned to a study group and a control group. miR-27a and miR-23a in peripheral blood were detected,andthe diagnostic value of these miRs for POF were ana-lyzed. miRs in the study group were detected again after treatment. The correlation between these miRs and modi-fied Kupperman score was analyzed.According to the cut-off values of miRs,the study group was subdivided into a high-efficacy group and a low-efficacy group,the differences among the two groups and the control group were com-pared. Results MiR-27a and miR-23a were reliable for diagnosis of POF,the best cut-off value was 2.29 and 1.95 respectively.After treatment,the miRs decreased in the study group(P<0.05).MiR-27a and miR-23a were positively correlated with the modified Kupperman score(P < 0.001). All indexes detected in high-efficacy group were close to those in the control group(P>0.05).Conclusions MiR-27a and miR-23a obviously decreases in women with POF after treatment,these miRs are helpful for assessing the efficacy.