Research progress on the role of non-coding RNAs in laryngeal squamous cell carcinoma / 中国肿瘤临床

ABSTRACT

Non-coding RNAs (ncRNAs) are a class of RNAs that do not encode proteins, including microRNAs (miRNAs), long non-cod-ing RNAs (lncRNAs), and circular RNAs (circRNAs). The ncRNAs play a vital role not only in the regulation of biological processes but al-so in the development of a variety of diseases, including cancer. The ncRNAs show significant clinical value in the diagnosis, prognosis, and therapy of laryngeal cancer (LC). Laryngeal squamous cell carcinoma (LSCC), the most common pathological type of LC, shows a re-cent trend in increasing incidences with a serious impact on human health and quality of life. In this paper, we summarize the research progress in recent years, and review the role of miRNAs, lncRNAs, and circRNAs in the development and progression of LC.