Neonatal necrotizing enterocolitis:advance on mechanism of small-molecule drugs / 中国小儿急救医学

ABSTRACT

Necrotizing enterocolitis(NEC) is the most common disease of gastrointestinal tract in neonate,and is an important cause of neonatal death,especially in premature. Its pathogenesis has not be clear and tends to be multifactorial,leading to the lack of effective prevention and treatment strategies. With the de-velopment of neonatal intensive care unit and the gradually improvement of the nursing level,the diagnostic detection rate of NEC has increased significantly. In addition to conventional surgery and conservative treat-ment,the research and development of new drugs targeting at NEC has been carried out in-depth,including octreotide,erythropoietin,amino acid and all trans retinoic acid. Through the analysis and summary of the mechanism and clinical application of these small-molecule drugs in the treatment of NEC,this review aimed at retrospecting the research progress of NEC drug treatment in recent years to provide relevant background knowledge for clinical prevention,treatment and drug research and development of NEC.