Evaluation of high-risk human papilloma virus infection inducing cervical cancer / 医学研究生学报

ABSTRACT

The oncogenic mechanism of human papilloma virus (HPV) has been elucidated,and high-risk HPV (HR-HPV) infection may cause malignancies such as cervical cancer.HR-HPV infection of the cervix is very common,while only a few cases of such infection develop into malignancy.Therefore,the evaluation of oncogenic risk of cervical HPV infection is of great clinical significance.Persistent HR-HPV infection of the cervix is mainly caused by immunological dysfunction-induced failure of HPV elimination and supposed to be the precondition of cervical cancer,while the type of HPV is an important factor for carcinogenesis of epithelial cells.