An association study of ATXN2 gene rs7969300 polymorphism with schizophrenia / 中华行为医学与脑科学杂志
Chinese Journal of Behavioral Medicine and Brain Science
;
(12): 904-906, 2017.
Artículo
en Chino
| WPRIM
| ID: wpr-666374
ABSTRACT
Objective To assess the association between rs7969300 polymorphism of ATXN2 gene and schizophrenia.Methods Totally 1 207 schizophrenia patients diagnosed in accordance with Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition(DSM-Ⅳ) and 1 120 healthy controls were involved.The rs7969300 gene SNP locus of ATXN2 gene was detected by ligase detection reaction polymerase chain reaction (PCR).PLINK software was used for statistical analysis.Results The results showed that there were no significantly different genotype frequencies(Schizophrenia patients(C/C240,C/T537,T/T394),health controls (C/C208,C/T521,T/T368),x2 =1.001,P=0.606) and allele frequencies (Schizophrenia patients (C 1017,T1325),health controls (C937,T1257),x2 =0.238,P=0.626) of rs7969300 polymorphism between schizophrenia patients and healthy controls.Conclusion This study does not support that ATXN2 rs7969300 is a susceptibility locus for schizophrenia.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Guía de Práctica Clínica
Idioma:
Chino
Revista:
Chinese Journal of Behavioral Medicine and Brain Science
Año:
2017
Tipo del documento:
Artículo
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