Osteoblasts regulate global energy metabolism / 中华内分泌代谢杂志

ABSTRACT

Skeleton has been proven to be an endocrine organ. Osteoblasts,the bone-forming cells in the skeleton,can secret osteocalcin which regulates global energy metabolism and male fertility in its undercarboxylated form and lipocalin 2 which influences appetite through binding to MC4R in the hypothalamus. Being a highly metabolic cell,osteoblast needs lots of energy through utilizing glucose and fatty acid to support its proliferation,differentiation, and mineralization. Recent data have shown the consumption change of fuels by osteoblasts, which contributes to global energy metabolism. Wnt/β-catenin signaling in osteoblasts is very important for bone formation,and disruption or constitutive activation of this pathway through gene editing may influence global energy metabolism. Through interacting with Wnt/β-catenin signaling,parathyroid hormone and sclerostin monoclonal antibody perform their anti-osteoporosis effect,and affect glucose homeostasis,insulin sensitivity,lipid metabolism and browning of peripheral adipose tissue. Though great progress has been made to understand the regulation of energy metabolism by bone during recent years,a lot of questions still remain to be answered.