Improvement of Synthesis Technology for Sodium Picosulfate / 中国药房
China Pharmacy
;
(12): 4404-4406, 2017.
Artículo
en Chino
| WPRIM
| ID: wpr-667026
ABSTRACT
OBJECTIVE:
To improve the synthesis technology of sodium picosulfate.METHODS:
The synthesis technology of sodium picosulfate was improved by changing reaction solvent,charging sequence,refined method and formation of crystal water. Using phenol as raw material,it was condensed with 2-pyridinecarboxaldehyde to achieve 4,4′-(pyridin-2-ylmethylene)diphenol, and its yield rate was investigated. Sodium picosulfate was obtained after esterification,salification,formation of crystal water, and then its purity was determined.RESULTS:
The yield rate of key intermediate 4,4′-(pyridin-2-ylmethylene) diphenol reached above 88%,and the purity of refined products reached over 99.5%. Sodium picosulfate monohydrate was stable,and the content of single impurity was less than 0.1%.CONCLUSIONS:
The improved technology is simple with mild conditions,and suitable for large-scale production.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
China Pharmacy
Año:
2017
Tipo del documento:
Artículo
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