Dynamic Observation of Serum CXCL-12 in Patients with Different Subtypes of Acute Ischemic Stroke / 现代检验医学杂志

ABSTRACT

Objective To observe the dynamic change of serum CXCL-12 in patients with different subtypes of acute ischemic stroke.Methods 141 patients with acute ischemic stroke from January 2014 to June 2016 were recruited to participate in the study as stroke group.According to TOAST classification,they were divided into LAA group (52 cases),SAO group (54 cases) and CE group (35 cases).60 healthy physical examination patients in Affiliated Hospitd of Yan'an University physical examination centre in same time were selected as control group.Serum CXCL-12 of stroke patients were detected at admission,3th day,7th day and 14th day after stroke.Results Compared with the control group,the serum CXCL-12 level at four different time during acute stage were higher in three subgroups.Serum CXCL-12 in patients of three stoke subgroups was significantly increase within 24 hour after stroke.And it would peak at 3th day.Then,the level of serum CXCL-12 began to fall.Multivariate Logistics analysis showed that serum CXCL-12 level in patients with three different stroke subgroups at 7th day after stroke was the risk factor of poor prognosis.Conclusion For the patients with different subtypes of acute ischemic stroke,the serum CXCL-12 levels increased significantly.Moreover,the high level of serum CXCL-12 may correlate with poor prognosis.