Effect of rocuronium on muscle relaxants time in patients with different types of cancer / 中国基层医药

ABSTRACT

Objective To observe the effect of rocuronium on muscle relaxation time in patients with different types of cancer.Methods Sixty-four patients with tumor were enrolled.The patients underwent tumor resection under general anesthesia.They were divided into malignant tumor group (control group) and benign tumor group (observation group) according to different tumor type,32 cases in each group.Remifentanil,propofol,rocuronium were intravenously injected to induce anesthesia.The first convulsive response (T1) in the four strangulated stimuli up to the maximum inhibition of tracheal intubation and recorded time.Intravenous infusion of propofol,plasma concentration of 3-5μg/mL and intermittent intravenously injected remifentanil maintenance anesthesia.50 mg of rocuronium bromide diluted in 0.9％ NaC1 50ml,when T1 returned to 10％,the patients were given intravenous infusion of dilute rocuronium,to maintain patients with T1 in 5％ to 10％,until the patients'consciousness recovery,removal of tracheal tube.Results There were no statistically significant differences in SBP,DBP,MAP and HR between the two groups (t =0.15,P =0.44;t =0.17,P =0.43;t =0.09,P =0.46;t =0.31,P =0.38;).The DBP,MAP,HR levels increased during intubation,SBP decreased,and the differences of SBP and DBP were statistically significant (t =2.33,P =0.01;t =2.18,P =0.02;t =3.44,P =0.00;t =3.09,P =0.00).Muscle relaxation index:The onset time [(98.28 ± 19.97) s],maximum effect duration [(19.97 ± 1.80) s],T1 recovered to 10％ [(26.45 ±0.94) min],T1 recovered from 10％ to 25％ [(13.14 ± 1.12) min],the recovery index[(11.67 ± 0.36) min] in the observation group were better than those in the control group (t =2.57,P =0.01;t =3.11,P =0.00;t =3.127,P =0.00;t =5.23,P =0.00;t =15.31,P =0.00).The tracheal intubation condition of the observation group was superior to that of the control group,but the difference was not statistically significant (P ＞ 0.05).Conclusion There is no statistically significant difference in vital signs between patients with benign and malignant tumors after rocuronium bromide,but the effect of rocuronium bromide on muscle is more sensitive in benign tumor than malignancy,and the onset time and recovery time is shortened.The overall intubation conditions have no significant differences.In the future selection of rocuronium bromide as muscle relaxants in the case of patients with benign and malignant tumors,can choose the appropriate anesthesia,in terms of dose,additional frequency should be considered.