Clinical study of Xiao'er Qingfeihuatan oral solution in the treatment of children with chronic cough / 中国基层医药

ABSTRACT

Objective To investigate the clinical efficacy of Qingfeihuatan oral solution in the treatment ofchildren with chronic cough.Methods According to the digital table,a total of 116 patients with cough variantasthma induced by chronic cough were randomly divided into control group and observation group,each group had58 cases.The two groups were given budesonide and formoterol fumarate powder for treatment,on this basis,theobservation group added Xiao'er Qingfeihuatan oral solution,the two groups were continuously treated for 4 weeks.Thechanges of lung function indicators,clinical efficacy and adverse reaction etc were observed.Results Aftertreatment,the clinical total effective rate of the observation group was 94.8％,which of the control group was 77.6％,the difference was statistically significant (x2 =3.625,P ＜ 0.05).The lung function indicators of FEV,FEV1 andFEV1/FEV in the two groups had statistically significant differences between before and after treatment (all P ＜0.05),but the pulmonary function indicators of FEV,FEV1 and FEV1/FEV in the observation group compared withthe control group had statistically significant differences (all P ＜ 0.05).The incidence rate of adverse reactions in theobservation group was 13.8％,which in the control group was 15.5％,the difference was not statistically significant(x2 =0.034,P ＞ 0.05).Conclusion On the basis of routine treatment,Qingfeihuatan oral solution in the treatmentof children with chronic cough can significantly improve the pulmonary function of patients,improve the clinicaltreatment effect,and has good safety and great clinical significance.