Clinical observation of budesonide suspension combined with antibiotics in the treatment of children with acute otitis media / 中国基层医药

ABSTRACT

Objective To observe the clinical efficacy of budesonide suspension combined with antibiotics in the treatment of children with acute otitis media.Methods 256 children with acute otitis media in Shaoxing Central Hospital from January 2016 to December 2016 were selected,and they were randomly divided into observation group and control group by using the method of random number table,128 cases in each group.Both two groups were given antibiotic therapy (azlocillin sodium),on this basis,the observation group was given budesonide suspension,the control group was given chloramphenicol ear drops.At the end of treatment,the treatment effect of the two groups was compared.Results Compared with the control group,the improvement of hearing in the observation group was significantly improved (x2 =21.05,P ＜ 0.01),the rate of tympanic effusion was significandy lower (t =15.30,P ＜ 0.01),and the effective decrease rate of tympanic cavity pressure was significantly higher (t =10.61,P ＜ 0.01).The clinical symptom score of the observation group was significantly reduced,and the degree of improvement was much better than that of the control group (t =16.99,P ＜ 0.01).The onset time and hospitalization time of the observation group were significantly shortened,and the differences were statistically significant (t =13.37,13.89,all P ＜ 0.01).The total effective rate of the observation group was 95.3％,which of the control group was 78.9％,and there was statistically significant difference between the two groups (x2 =20.19,P ＜0.01).The incidence rate of adverse reactions in the observation group was significantly lower than that in the control group,the difference was statistically significant (x2 =8.07,P ＜ 0.05).Conclusion Budesonide suspension combined with antibiotics in the treatment of children with acute otitis media has significant effect,it is conducive to reduce the formation of tympanic effusion,improve children's hearing and treatment effect,and worthy of further clinical application.