Expression and Clinical Significance of Serum Long Chain Non-encoded RNA ANRIL in Chronic Heart Failure Patients / 中国循环杂志
Chinese Circulation Journal
;
(12): 1095-1098, 2017.
Artículo
en Chino
| WPRIM
| ID: wpr-667876
ABSTRACT
Objective:
To explore the expression and clinical significance of serum long chain non-encoded RNAANRIL (LncRNA ANRIL) in chronic heart failure (CHF) patients.Methods:
Our research included in 2 groups CHF group, n=120 patients treated in our hospital and Control group, n=28 healthy subjects at the same period of time. Based on NYHA classification, CHF patients were further divided into 4 subgroups NYHAⅠ subgroup, n=28, NYHA Ⅱ subgroup, n=34, NYHA Ⅲ subgroup, n=35 and NYHA Ⅳ subgroup, n=23. Expressions of serum ANRIL and cystatin C were examined by real time fluorescence quantitative PCR (QRT-PCR) and compared between 2 groups; the relationship between ANRIL, cystatin C and cardiac function were studied.Results:
Compared with Control group, CHF group had increased serum levels of ANRIL and cystatin C, P<0.05. ANRIL expression was gradually increasing by cardiac function decreasing in CHF I to CHF Ⅳ subgroups, P<0.05. Correlation analysis found that serum level of ANRIL was positively related to cystatin C (r=0.873, P<0.001). ANRIL was elevated by increased left ventricular end diastolic diameter and decreased ejection fraction, both P<0.05.Conclusion:
Serum ANRIL level has been related to CHF at certain degree which may indirectly reflect the severity of HF in relevant patients.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Circulation Journal
Año:
2017
Tipo del documento:
Artículo
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