Observation on the Curative Effect of Calcipotriol in the Treatment of Psoriasis Vulgaris / 医学研究杂志

ABSTRACT

Objective To investigate the effect of calcipotriol in the treatment of psoriasis vulgaris.Methods 306 patients with stable psoriasis vulgaris were randomly divided into control group (n =153) and experimental group (n =153).Patients received in 2 groups received Vitamin C,folic acid and narrow-band UVB treatment.The control group was treated with clobetasol propionate ointment,those and in the experimental group was treated with topical ointment of calcipotriol.Scores of PASI and dermatological quality of life (DLQI)were measured,and the therapeutic effect,the serum levels of inflammatory cytokines,T lymphocyte subpopulations and skin barrier function were compared between the two groups.Results Compared with before treatment,levels of IFN-γ,IL-2,IL-17 and IL-18 in the two groups decreased (P ＜ 0.01),levels of CD3 +,CD4 + and CD4 +/CD8 + increased (P ＜ 0.01),levels of CD8 + decreased (P ＜0.01),levels of sebum content,water content of cuticle increased (P ＜ 0.01),levels of PH value decreased (P ＜ 0.01),PASI score,DLQI score decreased (P ＜ 0.01).Compared with the control group,the levels of IFN-γ,IL-2,IL-17 and IL-18 were lower (P ＜ 0.01),levels of CD3 +,CD4 + and CD4 +/CD8 + were higher (P ＜0.01),levels of CD8 + was lower(P ＜0.01),sebum content,water content of cuticle were higher (P ＜ 0.01),PH value was lower(P ＜0.01),PASI score and DLQI score were lower(P ＜0.01).Conclusion The efficacy of calcipotriol in treating psoriasis vulgaris is significant,worth of clinical promotion.