Aptamer-based technologies in the detection of marine biotoxins / 国际药学研究杂志

ABSTRACT

Aptamers are kinds of short single-stranded deoxyribonucleic acid(ssDNA)or ribonucleic acid(RNA)selected in vitro using SELEX(systematic evolution of ligands by exponential enrichment). They can effectively bind various targets such as ami-no acids,carbohydrates,proteins,cells and viruses,with the advantages of simple operation,high sensitivity and low cost. This arti-cle outlines the basic principles,advantages and applications of aptamer technology. It also summarizes the features and hazards of ma-rine biotoxins,and introduces the application prospects of aptamer technology in the detection of marine biotoxins.