Preliminary study of carboprost tromethamine for reducing postpartum hemorrhage in high-risk caesarean section / 重庆医学

ABSTRACT

Objective To explore the effect of carboprost tromethamine in high misk cesarean section for preventing and re-ducing postpartum hemorrhage and their side-effect .Methods 150 women underwent cesarean section with high-risk postpartum hemorrhage were randomly divided into three groupsgroup A (50 cases only using oxytocin) ,group B (50 cases only using carbo-prost tromethamine) and group C (50 cases using carboprost tromethamine and oxytocin) ,which were injected medicine immediate-ly after fetal disengagement .The blood loss (2 h and 24 h) ,hemoglobin ,hematocrit ,uterine contraction ,vital signs and extra treat-ment were compared among three groups .Results The amount of blood loss and the reduction of hemoglobin and hematocrit after the cesarean section in group B ,C were obviously lower than that of group A (P<0 .05) .In group B and C ,the rate of additional in-tervention was lower than group A .The incidence rate of side-effect in group B ,C was notably higher than that of group A (P<0 .01) .Conclusion Carboprost tromethamine injection in caesarean section can effectively decrease the loss of bleeding ,but the side-effect of carboprost tromethamine should be focus on .