Risk factors for dry eye / 眼科新进展

ABSTRACT

Objective To explore the risk factors for dry eye (DE) and its incidence.Methods Together 564 patients (564 eyes) were included in the study,and questionnaires were used to evaluate the symptoms,signs and general condition of the subjects with dry eye.Data were analyzed by using SPSS 16.0 software.x2 test and t-test were used to analyze the differences among groups,and logistic regression analysis was used to evaluate the relationship between risk factors and dry eye.Results Factors were significantly associated with increased severe DE symptoms included dry mouth (OR =2.89,95％ CI1.6-5.5;P =0.001) and gastrointestinal ulcer medications (OR =2.60,95％ CI1.1-5.1;P =O.04).In addition,administration of artificial tears could aggravate the signs of severe dry eye (OR =2.1,95％ CI1.2-3.2;P =0.01).Risk factors associated with aqueous tear deficiency were dry mouth (OR =1.92,95％ CI1.02-3.60;P =0.04) and diuretics (OR =6.00,95 ％ CI1.3-41.0;P =0.02).Risk factors associated with meibomian gland dysflmction included old age (OR =1.02,95％ CI1.05-1.09;P =0.000),male sex (OR =1.42,95％ CI1.04-2.6;P =O.02),arthritis (OR =8.00,95％ CI1.0-59.0;P =0.02),and administration of an antihypertensive drugs (OR =2.85,95％ CI1.3-5.7;P =0.01).The only risk factor associated with corneal staining was dry mouth (OR =2.21,95％ CI1.1-5.4;P=0.02).Conclusion Different risk factors have different effects on dry eye,indicating that different subtypes of dry eye have different pathophysiological mechanisms.