Preparation and Preliminary Stability of Candesartan Cilexetil Tablets / 中国药师
China Pharmacist
;
(12): 664-668, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-669963
ABSTRACT
Objective:
To prepare and optimize candesartan cilexetil tablets,and study the stability preliminarily.Methods:
The formula was optimized by Box-Behnken experiment design,the ratio of lactose to pregelatinized starch( X1 ),the amount of disintegrant ( X2 ,%)and the amount of lubricant( X3 ,%)were selected as the independent variables,and weight difference( Y1 ,%),friability ( Y2 ,%),disintegration time( Y3 ,%)and candesartan cilexetil dissolution( Y4 ,%)were the dependent variables. The release rate of candesartan cilexetil tablets and the reference tablets were compared by similarity factor( f2 value). Preliminary stability was studied by high-temperature test,high-humidity test and illumination test.Results:
The optimal formula of the tablets was as followsthe ratio of lactose to pregelatinized starch was 71,the amount of disintegrant was 5. 5%,and the amount of lubricant was 0. 5%. The f2 for the candesartan cilexetil tablets and the reference tablets in different dissolution meda was 60. 62,73. 34,66. 95 and 68. 60,respec-tively.Conclusion:
The formula design is reasonable,the preparation process is feasible and the quality can be controlled.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
China Pharmacist
Año:
2015
Tipo del documento:
Artículo
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