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Study on LC-MS/MS Method for the Detection of 10 Quinolone Drugs Illegally Added in Health Foods and Chinese Traditional Patent Medicines / 中国药师
China Pharmacist ; (12): 2162-2164, 2015.
Artículo en Chino | WPRIM | ID: wpr-670139
ABSTRACT

Objective:

To establish a specialized detection method for quinolone drugs illegally added in health foods and Chinese traditional patent medicines.

Methods:

LC-MS/MS was used to simultaneously screen pipemidic acid, norfloxacin, ciprofloxacin, lomefloxacin, enoxacin, fleroxacin, pefloxacin, sparfloxacin, gatifloxacin and ofloxacinan in health foods and Chinese traditional patent medicines. Qualitative and quantitative analysis and methodology validation were studied as well.

Results:

Under the conditions of the analysis method, the 10 quinolone drugs added illegally obtained a good separation on a chromatographic column. With the two grade mass spectrum for the qualitative analysis and the peak area of multiple reactions monitoring mode for the quantitative calculation, the method was specific and sophisticated. The recovery and linear relationship met the demand of screening.

Conclusion:

The method is simple and accurate in the detection of quinolone drugs in health food and Chinese traditional patent medicines.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio diagnóstico / Investigación cualitativa Idioma: Chino Revista: China Pharmacist Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio diagnóstico / Investigación cualitativa Idioma: Chino Revista: China Pharmacist Año: 2015 Tipo del documento: Artículo