Growth inhibition effect of 5-azaC on the proliferation of HSG cells in vivo / 实用口腔医学杂志
Journal of Practical Stomatology
;
(6)2000.
Artículo
en Chino
| WPRIM
| ID: wpr-670868
ABSTRACT
objective:
To study the growth inhibition effect of 5azaC on human salivary gland cell line HSG.Methods:
HSG cells were exposed to 5-azaC at 5?10~ -6 mol/L and 10?10~ -6 mol/L respectively for 3 days. The proliferation of in vitro cultured HSG cells was studied by cell counting. The in vivo growth of HSG cells was investigated by tumor weight measurement in nude mouse models of HSG tumor induced by transplantation of the cells subcutaneously.Results:
5 azaC inhibited HSG cell proliferation by 85% and 95% respectively at above mentioned doses. In the 3-week tumor growth study, the growth of the tumor induced by 5?10~ -6 mol/L 5azaC treated cell was inhibited by 74.8%.Conclusion:
5azaC can inhibit the growth of HSG cells in vitro and in vivo.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Journal of Practical Stomatology
Año:
2000
Tipo del documento:
Artículo
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