Identification and biological characteristic of melatonin receptor in human embr yonic nervous system / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 12-14, 2001.
Artículo
en Chino
| WPRIM
| ID: wpr-671522
ABSTRACT
Objective:
To verify whether there exists melatoni n(Mel) receptor in human embryonic nervous system.Methods:
Spec ific binding of Mel to embryonic brain and spinal cord was measured by radioliga nd binding assay.Results:
125 I-Mel binding s ites in optomeninx was the most, in eptochiasm and sniff ball was next; GTPγS d ose-de pendently inhibited the binding.Conclusion:
The results demonst rate the presence of specific binding of Mel in human embryonic brain and spinal cord. GTPγS has some effect on 125 I-Mel specific binding,support ing the theory that Mel receptor is coupled to inhibitory G-proteins.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
Idioma:
Chino
Revista:
Academic Journal of Second Military Medical University
Año:
2001
Tipo del documento:
Artículo
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