Expression of stratum corneum chymotryptic enzyme and its significance in cervical adenocarcinoma / 肿瘤研究与临床

ABSTRACT

Objective To investigate the expression of stratum corneum chymotuptic enzyme (SCCE) and its significance in human cervical adenocarcinoma.Methods Immunohistochemistry was used to detect the expressions of SCCE,ER,CEA and Vimentin in tissues from the group of 45 cervical adenocarcinoma patients,group of 24 cervical glandular intraepithelial neoplasia (CGIN) patients and group of 24 normal cervical tissues.Results The expression of SCCE was 84.44 ％ (38/45),58.33 ％ (14/24) and 8.33 ％ (2/24) in 3 groups respectively.The SCCE expression from group of cervical adenocarcinoma were more significantly than that of normal cervical tissues (P ＜ 0.012 5),the expression of SCCE from group of CGIN were more significantly than that of normal cervical tissues (P ＜ 0.012 5),but there was no difference between the cervical adenocarcinoma and the CGIN on the expression of SCCE (P ＞ 0.012 5).Conclusion SCCE could be recommended as a new biomarker for the early screening cervical adenocarcinoma and as an additional marker for the prognosis of cervical adenocarcinoma.