Changes of CA125 and PIIINP (Procollagen-3-N-terminal Peptide) in Peritoneal Dialysis Patients with Low GDP Solution / 대한신장학회잡지
Korean Journal of Nephrology
;
: 118-125, 2005.
Artículo
en Coreano
| WPRIM
| ID: wpr-67227
ABSTRACT
BACKGROUND:
The bioincompatability of the conventional peritoneal dialysis can be partly attributed to the presence of GDPs, which are generated during the heat sterilization. Formation of GDPs can be significantly reduced by the use of multi-chamber bag systems because high concentrated glucose is separated from alkaline lactate. In order to investigate whether multi-chamber bag system can improve the in vivo biocompatibility, we performed a randomized, prospective study comparing the multi-chamber bag system with the conventional PD system, measuring CA125 and PIIINP levels in the effluent dialysates as well as the other clinical and biochemical parameters.METHODS:
Forty five patients who were stable on CAPD were enrolled randomly assigned to experiment group (n=27), and control group (n=18). Overnight effluent was collected for measurement of CA125 and PIIINP and the other clinical, biochemical parameters were compared including the number of peritonitis, the ultrafiltration volume.RESULTS:
In patients treated with the multiple chamber bag system, there were significantly higher levels of CA125 and PIIINP from 1 month. No clinical and biochemical parameters influenced on their levels. The incidence of peritonitis or ultrafiltration volume did not differ between the two groups.CONCLUSION:
Using the low GDP solution resulted in a better preservation of peritoneal mesothelial mass and an improvement of local peritoneal homeostasis, which are supposed to contribute to the biocompatibility of peritoneal dialysis fluid.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Peritonitis
/
Ultrafiltración
/
Soluciones para Diálisis
/
Esterilización
/
Incidencia
/
Estudios Prospectivos
/
Diálisis Peritoneal
/
Diálisis Peritoneal Ambulatoria Continua
/
Ácido Láctico
/
Glucosa
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Nephrology
Año:
2005
Tipo del documento:
Artículo
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