Influence of open heart surgery under cardiopulmonary bypass on pancreatic beta cell function / 中华麻醉学杂志

ABSTRACT

Objective:To determine the influence of cardiopulmonary bypass(CPB) on human pancreatic bate cell function. Method:Twenty patients were divided into 2 group, groupⅠ(congenital heart disease,n=10). group Ⅱ(valvular heart disease,n=10). Blood samples were obtained from 20 patients at the following intervalsbefore anesthesia, before CPB, 15 min following CPB, 5 min after relaxing aorta, 20 min after CPB. The plasma insulin and C-peptide levels were measured with radioimmunoassay double-antibody technique,and blood glucose level with GOD-POD method. Result:The significant increases of blood glucose and insulin levels were observed during and after CPB in both groups(P