The expression of angiopoietin mRNA in hepatocellular carcinoma tissue and its relation with tumor angiogenesis and metastasis / 中国普通外科杂志

ABSTRACT

ObjectiveTo study the expression of angiopoietin in hepatocellular carcinoma tissue, and its relation with tumor angiogenesis and clinical significance. Methods Using immunohistochemistry and in situ hybridization, we observed the expression of angiopoietin 1(Ang 1) and angiopoietin 2(Ang 2) mRNA in 21 HCC patients and 5 normal liver tissues. The correlation between angiopoietin expression and several pathological markers was analyzed with computer statistical tools. Results Ang 1 equally expressed in tumor tissue, the adjacent noncarcinomatous tissue and normal liver. Ang 2 was highly expressed in tumor tissue, especially in tumor margin. The difference was significant between the group with metastasis and that without ( P