Effect of Tumor Promoter PMA on Cell-mediated lmmunity Ⅲ. PMA Inhibits Antigen Presentation by Spleen Adherent Cells / 中国免疫学杂志
Chinese Journal of Immunology
;
(12)1986.
Artículo
en Chino
| WPRIM
| ID: wpr-674517
ABSTRACT
TNP-conjugated spleen adherent cells (SAC) from normal BALB/c mice could stimulate lymph-node T lymphocytes (LNT) of 1, 3, 5-trinitrobenzene (TNCB) -primed syngeneic mice to proliferate in vitro. The proliferative response was suppressed when phorbol myristic acetate.(PMA) was present in the culture. SAC pretreated with PMA also suppressed markedly the response. Furthermore, PMA was shown to inhibit interleukin-1 (IL-1) production and/or secretion by macrophages in response to LPS stimulation in vitro. Therefore, the suppressive effect of PMA on antigen presentation seems to be due to its inhibitory effect on IL-1 production and/or secretion.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Immunology
Año:
1986
Tipo del documento:
Artículo
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