Experimental Study on Antagonistic Effects of Selenium on Methylmercury Neurotoxicity / 环境与健康杂志

ABSTRACT

Objective To study the antogonistic effects of selenium(Se) on methylmercury (MeHg) induced lipid peroxidation Methods SD rats were purfused perorally with Se and MeHg The effects on lipid peroxidation in rats' brain tissue caused by MeHg and the antagonistic effects of Se were observed Results Se could reduce the accumulation levels of MeHg in brain tissue and increase the GSH contents and GSH Px activities so as to inhibit the lipid peroxidation in brain tissue induced by MeHg and reduce LPO levels Conclusion Se at a certain dose could markedly antagonize MeHg induced lipid peroxidation as a result of reducation of the accumulative levels of MeHg in brain tissue and antagonizing lipid peroxidation induced by Se itself